Back: Sheridan Mikhail, Aadil Sheikh, Alec Ingros, Rebecca Modisette, Clayton Smith Front: Shuxuan Song, Kelsey Johnson, Keighley Reisenauer, Joe Taube (PI), Grace Killeen, Joelle Kim, Samantha Pena
Outgrowth of disseminated metastases is the major cause of mortality in cancer patients. In the Taube lab, we are investigating the molecular pathways and cellular properties which enable primary tumor cells to metastasize.
In normal tissues, epithelial cells form a well-structured barrier using a variety of adhesion molecules. However, aberrant activation of a conserved cellular program, termed epithelial-mesenchymal transition (EMT), facilitates the separation of epithelial cells from this tissue. When EMT occurs in epithelial tumors, the probability of metastatic dissemination is increased.
Our current work is focused on uncovering the regulatory mechanisms which facilitate EMT in both normal and cancerous settings, describing the specific targets and roles of these regulatory mechanisms and testing small molecule inhibitors of these proteins to ultimately lead to novel therapeutic strategies.
News and Updates
Another awesome year in the books! The lab got together at Dr. Taube’s house to celebrate everyone’s hard work and to send our seniors off well. We say goodbye to Emily Lin, Clayton Smith, and Samantha Pena who graduated this spring. They will be dearly...read more
Dr. Taube and Keighley were invited to attend the Houston Illuminate Fundraiser, alongside Dr. Tamar Carter (a new Biology hire for Tropical Disease). Robert Huff (1st year, Pitts Lab), and Dr. Dwayne Simmons (department Chair, hearing loss)....read more
Congratulations to Rebecca Modisette for winning an award for her poster at the Undergraduate Research and Scholarly Achievement symposium!read more
Both our own Dr. Joe Taube and collaborator Dr. Leigh Greathouse won the Outstanding Leadership in Undergraduate Research Award, following nominations from their students. Congrats to both! It is certainly well deserved.read more
Congratulations to Clayton Smith on defending his Honor’s thesis this past Monday (4/29/19)! First thesis defense in Taube Lab. Plus, Clayton won the Cornelia Smith Outstanding Biology Senior award [pictured]. Well done Clayton!read more
— Baylor University (@Baylor) February 13, 2019
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