Back: Wezley Griffin (PhD), Dustin Jaoude, Clayton Smith, Keighley Reisenauer, Beatriz Castro-Rodriquez, Alec Ingros, Aadil Sheikh | Front: Tim Philip, Joelle Kim, Dr. Joe Taube, Kelsey Johnson, Taylor Nesbit, Samantha Pena | Inset: Emily Lin

Research Focus

Outgrowth of disseminated metastases is the major cause of mortality in cancer patients. In the Taube lab, we are investigating the molecular pathways and cellular properties which enable primary tumor cells to metastasize.

In normal tissues, epithelial cells form a well-structured barrier using a variety of adhesion molecules. However, aberrant activation of a conserved cellular program, termed epithelial-mesenchymal transition (EMT), facilitates the separation of epithelial cells from this tissue. When EMT occurs in epithelial tumors, the probability of metastatic dissemination is increased.

Our current work is focused on uncovering the regulatory mechanisms which facilitate EMT in both normal and cancerous settings, describing the specific targets and roles of these regulatory mechanisms and testing small molecule inhibitors of these proteins to ultimately lead to novel therapeutic strategies.

News and Updates

Happy Spring 2019!

The Taube Lab is excited to start another semester and another year! We are one grad student and a few undergrads stronger, and have lots of exciting research on the horizon. To keep progress consistent, we are resolving to implement better time management techniques...

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Welcome, Shuxuan!

The Taube Lab is very excited to warmly welcome our newest addition: Shuxuan Song! She rotated with us at the beginning of the semester and left a wonderful impression. She is a first year PhD student coming to us from China, and has a rich history in medicine. We are...

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Kelsey and Keighley present at SABCS

SABCS (San Antonio Breast Cancer Symposium) was a valuable experience, getting the chance to interact with clinicians, translational researchers, and basic scientists. Keighley and Kelsey both presented on the third day of the nearly-week-long conference, but at...

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Taube Lab has landed @ SABCS!

The Taube Lab (Dr. Taube, Kelsey, and Keighley) have all made it safely to the San Antonio Breast Cancer Symposium. It’s an amazing, huge, international conference where scientists and physicians from all angles of breast cancer meet to learn from and discuss with...

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SABCS 2018

We are excited for the San Antonio Breast Cancer Symposium 12/4-8/2018 where both our doctoral students, Keighley and Kelsey, will be presenting their research. Keighley’s abstract on cancer stem cell sensitization to treatment with small-molecules has been...

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