Ismaeel A, Miserlis D, Papoutsi E, Haynatzki G, Bohannon WT, Smith RS, Eidson JL, Casale GP, Pipinos II, Koutakis P. Endothelial Cell-Derived Pro-fibrotic Factors Increase TGF-β1 Expression by Smooth Muscle Cells in Response to Cycles of Hypoxia Hyperoxia. Biochim Biophys Acta Mol Basis Dis. 2021 Sep 30:166278. doi: 10.1016/j.bbadis.2021.166278. Online ahead of print. PMID: 34601016

Wilburn D, Ismaeel A, Machek S, Fletcher E, Koutakis P. Shared and distinct mechanisms of skeletal muscle atrophy: A narrative review. Ageing Res Rev. 2021 Nov;71:101463. doi: 10.1016/j.arr.2021.101463. Epub 2021 Sep 15.PMID: 34534682

Ismaeel A, Greathouse KL, Newton N, Miserlis D, Papoutsi E, Smith RS, Eidson JL, Dawson DL, Milner CW, Widmer RJ, Bohannon WT, Koutakis P. Phytochemicals as Therapeutic Interventions in Peripheral Artery Disease. Nutrients. 2021 Jun 22;13(7):2143. doi: 10.3390/nu13072143. PMID: 34206667; PMCID: PMC8308302.

Duclot F, Sailer L, Koutakis P, Wang Z, Kabbaj M. Transcriptomic Regulations Underlying Pair-bond Formation and Maintenance in the Socially Monogamous Male and Female Prairie Vole. Biol Psychiatry. 2020 Dec 9:S0006-3223(20)32108-9. doi: 10.1016/j.biopsych.2020.11.022. Epub ahead of print. PMID: 33549315; PMCID: PMC8187463.

Mietus CJ, Lackner TJ, Karvelis PS, Willcockson GT, Shields CM, Lambert NG, Koutakis P, Fuglestad MA, Hernandez H, Haynatzki GR, Kim JKS, DeSpiegelaere HK, Pipinos II, Casale GP. Abnormal Microvascular Architecture, Fibrosis, and Pericyte Characteristics in the Calf Muscle of Peripheral Artery Disease Patients with Claudication and Critical Limb Ischemia. J Clin Med. 2020 Aug 8;9(8). doi: 10.3390/jcm9082575. PubMed PMID:32784470; PubMed Central PMCID:PMC7464726.

Ismaeel A, Papoutsi E, Miserlis D, Lavado R, Haynatzki G, Casale GP, Bohannon WT, Smith RS, Eidson JL, Brumberg R, Hayson A, Kirk JS, Castro C, Sawicki I, Konstantinou C, Brewster LP, Pipinos II, Koutakis P. The Nitric Oxide System in Peripheral Artery Disease: Connection with Oxidative Stress and Biopterins. Antioxidants (Basel). 2020 Jul 6;9(7). doi: 10.3390/antiox9070590. PubMed PMID:32640613; PubMed Central PMCID:PMC7402092.

Stamatis A, Grandjean P, Morgan G, Padgett RN, Cowden R, Koutakis P. Developing and training mental toughness in sport: a systematic review and meta-analysis of observational studies and pre-test and post-test experiments. BMJ Open Sport Exerc Med. 2020;6(1):e000747. doi: 10.1136/bmjsem-2020-000747. eCollection 2020. PubMed PMID:32577300; PubMed Central PMCID:PMC7299040.

Ismaeel A, Franco ME, Lavado R, Papoutsi E, Casale GP, Fuglestad M, Mietus CJ, Haynatzki GR, Smith RS, Bohannon WT, Sawicki I, Pipinos II, Koutakis P. Altered Metabolomic Profile in Patients with Peripheral Artery Disease. J Clin Med. 2019 Sep 14;8(9). doi: 10.3390/jcm8091463. PubMed PMID:31540015; PubMed Central PMCID:PMC6780416.

Ismaeel A, Holmes M, Papoutsi E, Panton L, Koutakis P. Resistance Training, Antioxidant Status, and Antioxidant Supplementation. Int J Sport Nutr Exerc Metab. 2019 Sep 1;29(5):539-547. doi: 10.1123/ijsnem.2018-0339. Review. PubMed PMID:30859847.

Ismaeel A, Kim JS, Kirk JS, Smith RS, Bohannon WT, Koutakis P. Role of Transforming Growth Factor-β in Skeletal Muscle Fibrosis: A Review. Int J Mol Sci. 2019 May 17;20(10). doi: 10.3390/ijms20102446. Review. PubMed PMID:31108916; PubMed Central PMCID:PMC6566291.

Hernandez H, Myers SA, Schieber M, Ha DM, Baker S, Koutakis P, Kim KS, Mietus C, Casale GP, Pipinos II. Quantification of Daily Physical Activity and Sedentary Behavior of Claudicating Patients. Ann Vasc Surg. 2019 Feb;55:112-121. doi: 10.1016/j.avsg.2018.06.017. Epub 2018 Aug 13. PubMed PMID:30114505; PubMed Central PMCID:PMC6340750.

Ismaeel A, Lavado R, Smith RS, Eidson JL, Sawicki I, Kirk JS, Bohannon WT, Koutakis P. Effects of Limb Revascularization Procedures on Oxidative Stress. J Surg Res. 2018 Dec;232:503-509. doi: 10.1016/j.jss.2018.07.024. Epub 2018 Aug 3. Review. PubMed PMID:30463765.

Ismaeel A, Brumberg RS, Kirk JS, Papoutsi E, Farmer PJ, Bohannon WT, Smith RS, Eidson JL, Sawicki I, Koutakis P. Oxidative Stress and Arterial Dysfunction in Peripheral Artery Disease. Antioxidants (Basel). 2018 Oct 19;7(10). doi: 10.3390/antiox7100145. Review. PubMed PMID:30347720; PubMed Central PMCID:PMC6210426.

Dale M, Fitzgerald MP, Liu Z, Meisinger T, Karpisek A, Purcell LN, Carson JS, Harding P, Lang H, Koutakis P, Suh M, Batra R, Mietus CJ, Casale G, Pipinos I, Baxter BT, Xiong W. Correction: Premature aortic smooth muscle cell differentiation contributes to matrix dysregulation in Marfan Syndrome. PLoS One. 2018;13(7):e0200985. doi: 10.1371/journal.pone.0200985. eCollection 2018. PubMed PMID:30011334; PubMed Central PMCID:PMC6047826.

Koutakis P, Ismaeel A, Farmer P, Purcell S, Smith RS, Eidson JL, Bohannon WT. Oxidative stress and antioxidant treatment in patients with peripheral artery disease. Physiol Rep. 2018 Apr;6(7):e13650. doi: 10.14814/phy2.13650. Review. PubMed PMID:29611350; PubMed Central PMCID:PMC5880878.

Xu J, Cui X, Li J, Koutakis P, Pipinos I, Tzeng E, Chen A, Sachdev U. Chloroquine improves the response to ischemic muscle injury and increases HMGB1 after arterial ligation. J Vasc Surg. 2018 Mar;67(3):910-921. doi: 10.1016/j.jvs.2017.01.021. Epub 2017 Mar 1. PubMed PMID:28259568; PubMed Central PMCID:PMC5581296.

Dale M, Fitzgerald MP, Liu Z, Meisinger T, Karpisek A, Purcell LN, Carson JS, Harding P, Lang H, Koutakis P, Suh M, Batra R, Mietus CJ, Casale G, Pipinos I, Baxter BT, Xiong W. Premature aortic smooth muscle cell differentiation contributes to matrix dysregulation in Marfan Syndrome. PLoS One. 2017;12(10):e0186603. doi: 10.1371/journal.pone.0186603. eCollection 2017. PubMed PMID:29040313; PubMed Central PMCID:PMC5645122.

Long CA, Timmins LH, Koutakis P, Goodchild TT, Lefer DJ, Pipinos II, Casale GP, Brewster LP. An endovascular model of ischemic myopathy from peripheral arterial disease. J Vasc Surg. 2017 Sep;66(3):891-901. doi: 10.1016/j.jvs.2016.07.127. Epub 2016 Sep 29. PubMed PMID:27693032; PubMed Central PMCID:PMC5374046.

Ha DM, Carpenter LC, Koutakis P, Swanson SA, Zhu Z, Hanna M, DeSpiegelaere HK, Pipinos II, Casale GP. Transforming growth factor-beta 1 produced by vascular smooth muscle cells predicts fibrosis in the gastrocnemius of patients with peripheral artery disease. J Transl Med. 2016 Feb 4;14:39. doi: 10.1186/s12967-016-0790-3. PubMed PMID:26847457; PubMed Central PMCID:PMC4743093.

Kamenskiy A, Miserlis D, Adamson P, Adamson M, Knowles T, Neme J, Koutakis P, Phillips N, Pipinos I, MacTaggart J. Patient demographics and cardiovascular risk factors differentially influence geometric remodeling of the aorta compared with the peripheral arteries. Surgery. 2015 Dec;158(6):1617-1627. doi: 10.1016/j.surg.2015.05.013. Epub 2015 Jun 19. PubMed PMID:26096560; PubMed Central PMCID:PMC4637258.

Koutakis P, Myers SA, Cluff K, Ha DM, Haynatzki G, McComb RD, Uchida K, Miserlis D, Papoutsi E, Johanning JM, Casale GP, Pipinos II. Abnormal myofiber morphology and limb dysfunction in claudication. J Surg Res. 2015 Jun 1;196(1):172-9. doi: 10.1016/j.jss.2015.02.011. Epub 2015 Feb 13. PubMed PMID:25791828; PubMed Central PMCID:PMC4512658.

Saunders NW, Koutakis P, Kloos AD, Kegelmeyer DA, Dicke JD, Devor ST. Reliability and validity of a wireless accelerometer for the assessment of postural sway. J Appl Biomech. 2015 Jun;31(3):159-63. doi: 10.1123/jab.2014-0232. Epub 2015 Jan 5. PubMed PMID:25558822.

Koutakis P, Miserlis D, Myers SA, Kim JK, Zhu Z, Papoutsi E, Swanson SA, Haynatzki G, Ha DM, Carpenter LA, McComb RD, Johanning JM, Casale GP, Pipinos II. Abnormal accumulation of desmin in gastrocnemius myofibers of patients with peripheral artery disease: associations with altered myofiber morphology and density, mitochondrial dysfunction and impaired limb function. J Histochem Cytochem. 2015 Apr;63(4):256-69. doi: 10.1369/0022155415569348. Epub 2015 Jan 9. PubMed PMID:25575565; PubMed Central PMCID:PMC4374059.

Thompson JR, Swanson SA, Haynatzki G, Koutakis P, Johanning JM, Reppert PR, Papoutsi E, Miserlis D, Zhu Z, Casale GP, Pipinos II. Protein concentration and mitochondrial content in the gastrocnemius predicts mortality rates in patients with peripheral arterial disease. Ann Surg. 2015 Mar;261(3):605-10. doi: 10.1097/SLA.0000000000000643. PubMed PMID:24670845; NIHMSID:NIHMS1001669.

Cluff K, Kelly AM, Koutakis P, He XN, Huang X, Lu YF, Pipinos II, Casale GP, Subbiah J. Surface-enhanced Raman spectral biomarkers correlate with Ankle Brachial Index and characterize leg muscle biochemical composition of patients with peripheral arterial disease. Physiol Rep. 2014 Sep 1;2(9). doi: 10.14814/phy2.12148. Print 2014 Sep 1. PubMed PMID:25247767; PubMed Central PMCID:PMC4270241.

Koutakis P, Weiss DJ, Miserlis D, Shostrom VK, Papoutsi E, Ha DM, Carpenter LA, McComb RD, Casale GP, Pipinos II. Oxidative damage in the gastrocnemius of patients with peripheral artery disease is myofiber type selective. Redox Biol. 2014;2:921-8. doi: 10.1016/j.redox.2014.07.002. eCollection 2014. PubMed PMID:25180168; PubMed Central PMCID:PMC4143812.

Saunders NW, Hanson N, Koutakis P, Chaudhari AM, Devor ST. Landing ground reaction forces in figure skaters and non-skaters. J Sports Sci. 2014;32(11):1042-9. doi: 10.1080/02640414.2013.877593. Epub 2014 Jan 30. PubMed PMID:24479611.

Thompson JR, Swanson SA, Casale GP, Johanning JM, Papoutsi E, Koutakis P, Miserlis D, Zhu Z, Pipinos II. Gastrocnemius mitochondrial respiration: are there any differences between men and women?. J Surg Res. 2013 Nov;185(1):206-11. doi: 10.1016/j.jss.2013.05.054. Epub 2013 Jun 4. PubMed PMID:23768768; PubMed Central PMCID:PMC3805671.

Weiss DJ, Casale GP, Koutakis P, Nella AA, Swanson SA, Zhu Z, Miserlis D, Johanning JM, Pipinos II. Oxidative damage and myofiber degeneration in the gastrocnemius of patients with peripheral arterial disease. J Transl Med. 2013 Sep 25;11:230. doi: 10.1186/1479-5876-11-230. PubMed PMID:24067235; PubMed Central PMCID:PMC3849592.

Kim JK, Zhu Z, Casale G, Koutakis P, McComb RD, Swanson S, Thompson J, Miserlis D, Johanning JM, Haynatzki G, Pipinos II. Human enterovirus in the gastrocnemius of patients with peripheral arterial disease. J Am Heart Assoc. 2013 Aug 6;2(4):e000082. doi: 10.1161/JAHA.113.000082. PubMed PMID:23920231; PubMed Central PMCID:PMC3828788.

Cluff K, Miserlis D, Naganathan GK, Pipinos II, Koutakis P, Samal A, McComb RD, Subbiah J, Casale GP. Morphometric analysis of gastrocnemius muscle biopsies from patients with peripheral arterial disease: objective grading of muscle degeneration. Am. J. Physiol. Regul. Integr. Comp. Physiol.. 2013 Aug 1;305(3):R291-9. doi: 10.1152/ajpregu.00525.2012. Epub 2013 May 29. PubMed PMID:23720135; PubMed Central PMCID:PMC3742999.

Saunders NW, Hanson NJ, Koutakis P, Chaudhari AM, Devor ST. Figure skater level moderates balance training. Int J Sports Med. 2013 Apr;34(4):345-9. doi: 10.1055/s-0032-1327653. Epub 2012 Nov 26. PubMed PMID:23184479.

Mukherjee M, Koutakis P, Siu KC, Fayad PB, Stergiou N. Stroke survivors control the temporal structure of variability during reaching in dynamic environments. Ann Biomed Eng. 2013 Feb;41(2):366-76. doi: 10.1007/s10439-012-0670-9. Epub 2012 Oct 13. PubMed PMID:23064865.

Koutakis P, Mukherjee M, Vallabhajosula S, Blanke DJ, Stergiou N. Path integration: effect of curved path complexity and sensory system on blindfolded walking. Gait Posture. 2013 Feb;37(2):154-8. doi: 10.1016/j.gaitpost.2012.06.027. Epub 2012 Jul 27. PubMed PMID:22840893; PubMed Central PMCID:PMC3485438.

Wurdeman SR, Koutakis P, Myers SA, Johanning JM, Pipinos II, Stergiou N. Patients with peripheral arterial disease exhibit reduced joint powers compared to velocity-matched controls. Gait Posture. 2012 Jul;36(3):506-9. doi: 10.1016/j.gaitpost.2012.05.004. Epub 2012 Jun 5. PubMed PMID:22677467; PubMed Central PMCID:PMC3407282.

Koutakis P, Johanning JM, Haynatzki GR, Myers SA, Stergiou N, Longo GM, Pipinos II. Abnormal joint powers before and after the onset of claudication symptoms. J Vasc Surg. 2010 Aug;52(2):340-7. doi: 10.1016/j.jvs.2010.03.005. PubMed PMID:20670775; PubMed Central PMCID:PMC2921796.

Koutakis P, Pipinos II, Myers SA, Stergiou N, Lynch TG, Johanning JM. Joint torques and powers are reduced during ambulation for both limbs in patients with unilateral claudication. J Vasc Surg. 2010 Jan;51(1):80-8. doi: 10.1016/j.jvs.2009.07.117. Epub 2009 Oct 17. PubMed PMID:19837536; PubMed Central PMCID:PMC4465243.