The CMB is a highly interdisciplinary environment. The major focus of the lab is investigating the pathophysiology of peripheral artery disease (PAD). Our research also focuses on the development of improved diagnostic and treatment methods for patients. PAD affects more than 10 million people in the U.S., and is common in people who are 65 and older. PAD is a chronic disease in which plaque builds up in the arteries to the legs. This can decrease blood supply to the legs, which can produce muscle damage in the lower extremities. Because of the muscle damage and leg pain from the obstructed blood flow, patients with PAD are limited in their walking ability. If the disease becomes more severe, non healing sores can also develop, which may be limb-threatening and require amputations.