Bodies of Work

• • Peer Reviewed Publications
  • Book Chapters
  • Patents
  • Publications Previous to Baylor University

Peer Reviewed Publications

Imaging-Guided Evaluation of the Novel Small-Molecule Benzosuberene Tubulin-Binding Agent KGP265 as a Potential Therapeutic Agent for Cancer Treatment:  Yihang Guo, Honghong Wang, Jeni L. Gerberich, Samuel O. Odutola, Amanda K. Charlton-Sevcik, Maoping Li, Rajendra P. Tanpure, Justin K. Tidmore, Mary Lynn Trawick, Kevin G. Pinney, Ralph P. Mason, Li Liu, Cancers, 2021, 13 (19), 4769.  https://doi.org/10.3390/cancers13194769

Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors Li Liu, Devin O’Kelly, Regan Schuetze, Graham Carlson, Heling Zhou, Mary Lynn Trawick, Kevin G. Pinney, Ralph P. Mason, Molecules, 2021, 26, 2551. https://www.mdpi.com/1420-3049/26/9/2551

Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anti-Cancer Agents Targeted Towards Tumor-Associated Hypoxia: Blake A. Winn, Laxman Devkota, Bunnarack Kuch, Matthew T. MacDonough, Tracy E. Strecker, Yifan Wang, Zhe Shi, Jeni L. Gerberich, Deboprosad Mondal, Alejandro J. Ramirez, Ernest Hamel, David J. Chaplin, Peter Davis, Ralph P. Mason, Mary Lynn Trawick, Kevin G. Pinney, Journal of Natural Products, 2020, 83, 4, 937-954. https://doi.org/10.1021/acs.jnatprod.9b00773

Synthesis and Biological Evaluation of Structurally Diverse a-Conformationally Restricted Chalcones and Related Analogues: Maguire CJ, Carlson GJ, Ford JW, Strecker TE, Hamel E, Trawick ML, Pinney KG, MedChemComm, 2019.  https://pubs.rsc.org/en/Content/ArticleLanding/2019/MD/C9MD00127A#!divAbstract

Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization: Haichan Niu, Tracy E. Strecker, Jeni L. Gerberich, James W. Campbell III, Debabrata Saha, Deboprosad Mondal, Ernest Hamel, David J. Chaplin, Ralph P. Mason, Mary Lynn Trawick, and Kevin G. Pinney, Journal of Medicinal Chemistry, 2019.  https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00551

Efficient Synthetic Methodology for the Construction of Dihydronaphthalene and Benzosuberene Molecular Frameworks Deboprosad Mondal, Haichan Niu, Kevin G. Pinney, Tetrahedron Letters, 2019, 60, 397-401.  https://www.sciencedirect.com/science/article/pii/S0040403918314758

Improved Methodology for the Synthesis of a Cathepsin B Cleavable Dipeptide Linker Widely Used in Antibody-Drug Conjugate Research Deboprosad Mondal, Jacob Ford, Kevin G. Pinney, Tetrahedron Letters, 2018, 59, 3594-3599.  https://www.sciencedirect.com/science/article/pii/S0040403918310025

Synthesis of Dihydronaphthalene Analogues Inspired by Combretastatin A-4 and their Biological Evaluation Casey J. Maguire, Zhi Chen, Vani P. Mocharla, Madhavi Sriram, Tracy E. Strecker, Ernest Hamel, Heling Zhou, Ramona Lopez, Yifan Wang, Ralph P. Mason, David J. Chaplin, Mary Lynn Trawick, Kevin G. Pinney,  Med. Chem. Commun., 2018, 9, 1649-1662.  https://pubs.rsc.org/en/content/articlelanding/2018/md/c8md00322j#!divAbstract

Synthesis and Biological Evaluation of a Water-Soluble Phosphate Prodrug Salt and Structural Analogues of KGP94, a Lead Inhibitor of Cathepsin L Erica N. Parker, Samuel O. Odutola, Yifan Wang, Tracy E. Strecker, Rajeswari Mukherjee, Zhe Shi, David J. Chaplin, Mary Lynn Trawick, Kevin G. Pinney,  Bioorganic and Medicinal Chemistry Letters, 2017, 27, 1304-1310. http://dx.doi.org/10.1016/j.bmcl.2016.12.039

 

The Vascular Disrupting Activity of OXi8006 in Endothelial Cells and Its Phosphate Prodrug OXi8007 in Breast Tumor Xenografts. Tracy E. Strecker, Samuel O. Odutola, Ramona Lopez, Morgan S. Cooper, Justin K. Tidmore, Amanda K. Charlton-Sevcik, Li Li, Matthew T. MacDonough, Mallinath B. Hadimani, Anjan Ghatak, Li Liu, David J. Chaplin, Ralph P. Mason, Kevin G. Pinney, and Mary Lynn Trawick, Cancer Letters, 2015, accepted, in press, doi: 10.1016/j.canlet.2015.08.021  https://www.sciencedirect.com/science/article/pii/S0304383515005613?via%3Dihub

Mechanistic considerations in the synthesis of 2-aryl-indole analogues under Bischler–Mohlau conditions. MacDonough, M. T.; Shi, Z.; Pinney, K. G. Tetrahedron Letters, 2015, 56, 3624-3629. [Invited by Professor John L. Wood for inclusion in a special Memorial Symposium-in-Print to honor Professor Harry Wasserman]  https://www.sciencedirect.com/science/article/pii/S0040403915001677

Evaluation of tumor ischemia in response to an indole-based vascular disrupting agent using BLI and ¹⁹F MRI. Heling Zhou, Rami R. Hallac, Ramona Lopez, Rebecca Denney, Matthew T. MacDonough, Li Li, Li Liu, Edward E. Graves, Mary Lynn Trawick, Kevin G. Pinney, and Ralph P. Mason,  American Journal of Nuclear Medicine and Molecular Imaging, 2015, 5(2), 143-153.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396009/

Synthesis of Structurally Diverse Benzosuberene Analogues and their Biological Evaluation as Anti-cancer Agents. Tanpure, R. P.; George, C. S.; Strecker, T. E.; Devkota, L.; Tidmore, J. K.; Lin, C.-M.; Herdman, C. A.; MacDonough, M. T.; Sriram, M.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorganic and Medicinal Chemistry, 21, 8019-8032, 2013.  https://www.sciencedirect.com/science/article/pii/S0968089613007293?via%3Dihub

Synthesis of 2-Aryl-3-Aroyl-Indole Salt (OXi8007) Resembling Combretastatin A-4 with Application as a Vascular Disrupting Agent. Hadimani, M. B.; MacDonough, M. T.; Ghatak, A.; Strecker, T. E.; Lopez, R.; Sriram, M.; Nguyen, B. L.; Hall, J. J.; Kessler, R. J.; Shirali, A. R.; Liu, L.; Garner, C. M.; Pettit, G. R.; Hamel, E.; Chaplin, D. J.; Mason, R. P.; Trawick, M. L.; Pinney, K. G. Journal of Natural Products, 76, 1668-1678, 2013.  https://pubs.acs.org/doi/10.1021/np400374w

Synthesis and Biological Evaluation of Indole-based, Anti-cancer Agents Inspired by the Vascular Disrupting Agent 2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006). MacDonough, M. T.; Strecker, T. E.; Hamel, E.; Hall, J. J.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G.Bioorganic and Medicinal Chemistry, 21, 6831-6843, 2013.  https://www.sciencedirect.com/science/article/pii/S0968089613006482

Small-Molecule Inhibitors of Cathepsin L Incorporating Functionalized Ring-Fused Molecular Frameworks. Song, J.; Jones, L. M.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Jantz, A.; Johansen, A.; Bayeh, L.; Soeung, V.; Snyder, L. K.; Lade, Jr., S. D.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorganic Medicinal Chemistry Letters, 23: 2801-2807, 2013.  https://www.sciencedirect.com/science/article/pii/S0960894X12016095

Initial Evaluation of the Antitumour Activity of KGP94, a Functionalized Benzophenone Thiosemicarbazone Inhibitor of Cathepsin L. Chavarria, G. E.; Horsman, M. R.; Arispe, W. M.; Kumar, G. D. K.; Chen, S.-E.; Strecker, T. E.; Parker, E. N.; Chaplin, D. J.; Pinney, K. G.; Trawick, M. L. European Journal of Medicinal Chemistry, 58: 568-572,2012.  https://www.sciencedirect.com/science/article/pii/S0223523412006435

Synthesis and Biochemical Evaluation of Thiochromanone Thiosemicarbazone Analogues as Inhibitors of Cathepsin L. Song, J.; Jones, L. M.; Kumar, G. D. K.; Conner, E. S.; Bayeh, L.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Chen, S.-E.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. ACS Medicinal Chemistry Letters, 3: 450-453,2012.  https://pubs.acs.org/doi/abs/10.1021/ml200299g

An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity. *Tanpure, R. P.; *George, C. S.; *Sriram, M.; Strecker, T. E.; Tidmore, J. K.; Hamel, E.; Charlton-Sevcik, A. K.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. MedChemComm, 3: 720-724, 2012.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682772/
[* denotes authors with equal contributions]

Regioselective Synthesis of Water Soluble Monophosphate Derivatives of Combretastatin A-1. Tanpure, R. P.; Nguyen, B. L.; Strecker, T. E.; Aguirre, S.; Sharma, S.; Chaplin, D. J.; Siim, B. G.; Hamel, E.; Lippert, J. W. III; Pettit, G. R.; Trawick, M. L.; Pinney, K. G. Journal of Natural Products 74: 1568-1574,2011.  https://pubs.acs.org/doi/abs/10.1021/np200104t

A Perspective on Vascular Disrupting Agents that Interact with Tubulin: Preclinical Tumor Imaging and Biological Assessment. Mason, R. P.; Zhao, D.; Liu, L.; Trawick, M. L.; Pinney, K. G. Integr. Biol. 3: 375-387, 2011.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071431/
(Invited contribution to honor Professor Mina J. Bissell for her lifetime contributions to the tumor microenvironment and research involving the extracellular matrix)

Functionalized Benzophenone, Thiophene, Pyridine, and Fluorene Thiosemicarbazone Derivatives as Inhibitors of Cathepsin L . Kumar, G. D. K.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Yoo, G. K.; Song, J.; Strecker, T. E.; Siim, B. G.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. Lett. 20: 6610-6615, 2010.  https://www.sciencedirect.com/science/article/pii/S0960894X1001317X

Regio- and Stereospecific Synthesis of Mono ß-D-Glucuronic Acid Derivatives of Combretastatin A-1. Tanpure, R. P.; Strecker, T. E.; Chaplin, D. J.; Siim, B. G.; Trawick, M. L.; Pinney, K. G. J. Nat. Prod. 73: 1093-1101, 2010.  https://pubs.acs.org/doi/abs/10.1021/np100108e

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Kumar, G. D. K.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Arispe, W. M.; MacDonough, M. T.; Strecker, T. E.; Chen, S.-E.; Siim, B. G.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. Lett. 20: 1415-1419, 2010. https://www.sciencedirect.com/science/article/pii/S0960894X09018137

Application of the McMurry Coupling Reaction in the Synthesis of Tri- and Tetra-arylethylene Analogues as Potential Cancer Chemotherapeutic Agents. Tanpure, R. P.; Harkrider, A. R.; Strecker, T. E.; Hamel, E.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. 17: 6993-7001, 2009.  https://www.sciencedirect.com/science/article/pii/S0968089609007615

Carbon-14 Radiosynthesis of Combretastatin A-1 (CA1) and its Corresponding Phosphate Prodrug (CA1P). Brown, R. T.; Murrell, V. L.; McMordie, A.; Sriram, M.; Pinney, K. G.; Sharma, S.; Chaplin, D. J. J. Labelled Compd. Rad., 52: 567-570, 2009.  https://onlinelibrary.wiley.com/doi/full/10.1002/jlcr.1676

Development of Synthetic Methodology Suitable for the Radiosynthesis of Combretastatin A-1 (CA1) and its Corresponding Prodrug CA1P. Shirali, A.; Sriram, M.; Hall, J. J.; Nguyen, B. L.; Guddneppanavar, R.; Hadimani, M. B.; Ackley, J. F.; Siles, R.; Jelinek, C. J.; Arthasery, P.; Brown, R. C.; Murrell, V. L.; McMordie, A.; Sharma, S.; Chaplin, D. J.; Pinney, K. G. J. Nat. Prod. 72: 414-421, 2009.  https://pubs.acs.org/doi/abs/10.1021/np800661r

Design, Synthesis and Biological Evaluation of Dihydronaphthalene and Benzosuberene Analogs of the Combretastatins as Inhibitors of Tubulin Polymerization in Cancer Chemotherapy. Sriram, M.; Hall, J. J.; Grohmann, N. C.; Strecker, T. E.; Wootton, T.; Franken, A.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. 16: 8161-8171, 2008.  https://www.sciencedirect.com/science/article/pii/S0968089608006639

Design, Synthesis, Biochemical, and Biological Evaluation of Nitrogen-Containing Triflouro Structural Modifications of Combretastatin A-4. Hall, J. J.; Sriram, M.; Strecker, T. E.; Tidmore, J. K.; Jelinek, C. J.; Kumar, G. D. K.; Hadimani, M. B.; Pettit, G. R.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. Lett. 18: 5146-5149, 2008.  https://www.sciencedirect.com/science/article/pii/S0960894X08008330

Combretastatin Dinitrogen-Substituted Stilbene Analogues as Tubulin-Binding and Vascular-Disrupting Agents. Siles, R.; Ackley, J. F.; Hadimani, M. B.; Hall, J. J.; Mugabe, B. E.; Guddneppanavar, R.; Monk, K. A.; Chapuis, J.-C.; Pettit, G. R.; Chaplin, D. J.; Edvardsen, K.; Trawick, M. L.; Garner, C. M.; Pinney, K. G. J. Nat. Prod. 71: 313-320, 2008.  https://pubs.acs.org/doi/abs/10.1021/np070377j

Design, Synthesis and Biochemical Evaluation of Novel Cruzain Inhibitors with Potential Application in the Treatment of Chagas’ Disease. Siles, R.; Chen, S.-E.; Zhou, M.; Pinney, K. G.; Trawick, M. L. Bioorg. Med. Chem. Lett. 16: 4405-4409,2006.  https://www.sciencedirect.com/science/article/pii/S0960894X0600583X

Synthesis and Characterization of 2,6-Bis-Hydrazinopyridine, and its Conversion to 2,6-Bis-Pyrazolypyridines. Brien, K. A.; Garner, C. M.; Pinney, K. G. Tetrahedron 62: 3663-3666, 2006.  https://www.infona.pl/resource/bwmeta1.element.elsevier-e62dd9f1-97d5-3a7d-ac17-5313fe9ef949

Design, Synthesis, and Biological Evaluation of Combretastatin Nitrogen-Containing Derivatives as Inhibitors of Tubulin Assembly and Vascular Disrupting Agents. Monk, K. A.; Siles, R.; Hadimani, M. B.; Mugabe, B. E.; Ackley, J. F.; Studerus, S. W.; Edvardsen, K.; Trawick, M. L.; Garner, C. M.; Rhodes, M. R.; Pettit, G. R.; Pinney, K. G. Bioorg. Med. Chem. 14: 3231-3244, 2006.  https://www.sciencedirect.com/science/article/pii/S0968089605012198?via%3Dihub

Synthesis and Crystal Structures of Two Novel 3,4,5-Trimethoxyphenyl Derivatives from (Z)-1-[(2′,3′-Dinitro-4′-Methoxy)-Phenyl]-2-[(3”,4”,5”-trimethoxy)-phenyl] Ethene. Miranda, M. G.; Norton, E. J.; Feazell, R. P.; Klausmeyer, K. K.; Pinney, K. G. J. Chem. Crystallogr. 36: 309-314, 2006. https://link.springer.com/article/10.1007/s10870-005-9065-1

Combretastatin A-4 Resistance in H460
Human Lung Carcinoma Demonstrates Distinctive Alterations in β-Tubulin Isotope Expression. Wehbe, H.; Kearney, C. M.; Pinney, K. G. Anticancer Res. 25: 3865-3870, 2005.  http://ar.iiarjournals.org/content/25/6B/3865.long

Combretastatin Family Member Oxi4503 Induces Tumor Vascular Collapse Through the Induction of Endothelial Apoptosis. Sheng, Y.; Hua, J.; Pinney, K. G.; Garner, C. M.; Kane, R. R.; Prezioso, J. A.; Chaplin, D. J.; Edvardsen, K. Int. J. Cancer 111: 604-610, 2004.  https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.20297  https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.20297

Synthesis and Biological Evaluation of 2-(4-Flourophenoxy)-2-Phenyl-Ethyl Piperazines as Seratonin-Selective Reuptake Inhibitors with a Potentially Improved Adverse Reaction Profile. Dorsey, J. M.; Miranda, M. G.; Cozzi, N. V.; Pinney, K. G. Bioorg. Med. Chem. 12: 1483-1491, 2004.  https://www.sciencedirect.com/science/article/pii/S0968089603008824?via%3Dihub

Synthesis of 4-Methoxy-3,5-Dinitrobenzaldehyde: A Correction to Supposed teleNucleophilic Aromatic Substitution. Monk, K. A.; Siles, R.; Pinney, K. G.; Garner, C. M. Tetrahedron Lett. 44: 3759-3761, 2003.  https://www.sciencedirect.com/science/article/pii/S0040403903007512

Oxi4503, a Novel Vascular Targeting Agent: Effects on Blood Flow and Antitumor Activity in Comparison to Combretastatin A-4 Phosphate. Hua, J.; Sheng, Y.; Pinney, K. G.; Garner, C. M.; Kane, R. R.; Prezioso, J. A.; Pettit, G. R.; Chaplin, D. J.; Edvardsen, K. Anticancer Res. 23: 1433-1440, 2003.  https://www.researchgate.net/publication/10696969_Oxi4503_a_novel_vascular_targeting_agent_Effects_on_blood_flow_and_antitumor_activity_in_comparison_to_combretastatin_A-4_phosphate

Synthesis, In Vitro, and In Vivo Evaluation of Phosphate Ester Derivatives of Combretastatin A-4. Hadimani, M. B.; Hua, J.; Jonklaas, M. D.; Kessler, R. J.; Sheng, Y.; Olivares, A.; Tanpure, R. P.; Weiser, A.; Zhang, J.; Edvardsen, K.; Kane, R. R.; Pinney, K. G. Bioorg. Med. Chem. Lett. 13: 1505-1508, 2003.  https://www.sciencedirect.com/science/article/pii/S0960894X03002063

Synthesis of Methoxy and Hydroxy Containing Tetralones: Versatile Intermediates for the Preparation of Biologically Relevent Molecules. Ghatak, A.; Dorsey, J. M.; Garner, C. M.; Pinney, K. G. Tetrahedron Lett. 44: 4145-4148, 2003.  https://www.sciencedirect.com/science/article/pii/S0040403903007159

2-(3-tert-Butyldimethylsiloxy-4-methoxyphenyl)-6-methoxy-3-(3,4,5-Trimethoxybenzoyl)indole. Hadimani, M. B.; Kessler, R. J.; Kautz, J. A.; Ghatak, A.; Shirali, A. R.; O’Dell, H.; Garner, C. M.; Pinney, K. G. Acta Cryst. C58: o330-o332, 2002.  https://journals.iucr.org/c/issues/2002/06/00/bk1630/

Preparation of New Anti-tubulin Ligands through a Dual-Mode, Addition-Elimination Reaction to a Bromo-Substituted a,β-Unsaturated Sulfoxide. Chen, Z.; Mocharla, V. P.; Farmer, J. M.; Pettit, G. R.; Hamel, E.; Pinney, K. G. J. Org. Chem. 65: 8811-8815, 2000.  https://pubs.acs.org/doi/abs/10.1021/jo0004761

Synthesis and Biological Evaluation of Aryl Azide Derivatives of Combretastatin A-4 as Molecular Probes for Tubulin. Pinney, K. G.; Mejia, M. P.; Villalobos, V. M.; Rosenquist, B. E.; Pettit, G. R.; Verdier-Pinard, P.; Hamel, E. Bioorg. Med. Chem. 8: 2417-2425, 2000.  https://www.sciencedirect.com/science/article/pii/S0968089600001760

A New Anti-tubulin Agent Containing the Benzo[b]Thiophene Ring System. Pinney, K. G.; Bounds, A. D.; Dingeman, K. M.; Mocharla, V. P.; Pettit, G. R.; Bai, R.; Hamel, E. Bioorg. Med. Chem. Lett. 9: 1081-1086, 1999.  https://www.sciencedirect.com/science/article/pii/S0960894X99001432

(E)-1-(3-Methoxy-4-Nitrophenyl)-2-(3,4,5-Trimethoxyphenyl)Ethane. Mullica, D. F.; Pinney, K. G.; Mejia, P.; Rosenquist, B. E.; Sappenfield, E. L. Acta Cryst. C54: 695-697,1998.

Characterization and Structural Analyses of Trimethoxy and Triethoxybenzo[b]Thiophene. Mullica, D. F.; Pinney, K. G.; Mocharla, V. P.; Dingeman, K. M.; Bounds, A. D.; Sappenfield, E. L. J. Chem. Crystallogr. 28: 289-295, 1998.  https://www.researchgate.net/publication/263145579_Characterization_and_structural_analyses_of_trimethoxy_and_triethoxybenzobthiophene

X-ray Structures of Two Methoxybenzo[b]thiophenes. Mullica, D. F.; Pinney, K. G.; Dingeman, K. M.; Bounds, A. D.; Sappenfield, E. L. J. Chem. Crystallogr. 26: 801-806, 1996.  https://link.springer.com/article/10.1007/BF01670312

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Book Chapters

Pinney, K. G.; Pettit, G. R.; Trawick, M. L.; Jelinek, C.; Chaplin, D. J. The Discovery and Development of the Combretastatins. In Antitumor Agents from Natural Products, 2nd Edition, D. Kingston, D. Newman, and G. Cragg, eds. Boca Raton, FL: CRC Press, Taylor and Francis Group, published October 3, 2011. 

Pettit, G. R.; Pinney, K. G. “The Combretastatins” included in the Chapter entitled: Major Milestones. In American Society of Pharmacognosy History, G. Cragg, ed., Anticipated availability 2009.

Pinney, K. G. Molecular Recognition of the Colchicine Binding Site as a Design Paradigm for the Discovery and Development of Vascular Disrupting Agents. In Vascular-targeted Therapies in Oncology, D. W. Siemann, ed., 95-121. London, UK: John Wiley & Sons, 2006.

Pinney, K. G.; Jelinek, C.; Edvardsen, K.; Chaplin, D. J.; Pettit, G. R. The Discovery and Development of the Combretastatins. In Antitumor Agents from Natural Products, D. Kingston, D. Newman, and G. Cragg, ed., 23-46. Boca Raton, FL: CRC Press, 2005.

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Patents

David J. Chaplin, Kishore Kumar Gaddale Devanna, Erica Parker, Kevin G. Pinney, Jiangli Song, Mary Lynn Trawick, “Compositions and Methods for Inhibition of Cathepsins” (United States Patent: US 9,873,668), issued January 23, 2018.

Compositions and Methods for Inhibition of Cathepsins

David J. Chaplin, Kishore Kumar Gaddale Devanna, Erica Parker, Kevin G. Pinney, Jiangli Song, Mary Lynn Trawick. (United States Patent: US 9,458,103), issued October 4, 2016.

Compositions and Methods for Inhibition of Cathepsins
David J. Chaplin, Kishore Kumar Gaddale Devanna, Erica Parker, Kevin G. Pinney, Jiangli Song, Mary Lynn Trawick. (United States Patent: US 8,877,967 B2), issued November 4, 2014.

Catechol Compositions and Use Thereof
David J. Chaplin, Klaus Edvardsen, Kevin G. Pinney, Joseph Anthony Prezioso, and Mark Wood.  (Canadian Patent: 2 516 078), issued April 29, 2014.

Combretastatin Analogs with Tubulin Binding Activity
Kevin G. Pinney, Madhavi Sriram. United States Patent (US 8,394,859), issued March 12, 2013.

Compositions and Methods with Enhanced Therapeutic Activity
David J. Chaplin, Klaus Edvardsen, Kevin G. Pinney, Joseph Prezioso, Mark Wood. United States Patent (US 8,198,302), issued June 12, 2012.

Indole-Containing and Combretastatin-Related Anti-Mitotic and Anti-Tubulin Polymerization Agents
Kevin G. Pinney, Feng Wang, Maria Del Pilar Mejia. European Patent (EP 1 214 298 B1), issued May 30, 2012.

Inhibitors of Cysteine Proteases and Methods of Use Thereof.
Rogelio Siles, Ming Zhou, Freeland J. Ackley, Kevin G. Pinney, Shen-En Chen, Wara Milenka Arispe-Angulo, Mary Lynn Trawick. United States Patent (US 8,173,696), issued May 8, 2012.

Serotonin Reuptake Inhibitors.
Kevin G. Pinney, Maria Graciela Miranda, James Michael Dorsey. United States Patent (US 7,893,261 B2), issued February 22, 2011.

Chromene-derivatives with anti-tubulin and vascular targeting activity
Kevin G. Pinney, Phyllis Arthasery, Anupama Shirali, Klaus Edvardsen, David J. Chaplin. European Patent (EP 1 751 128 B1), issued July 21, 2010.

Chromene-containing compounds with anti-tubulin and vascular targeting activity.
Kevin G. Pinney, Phyllis Arthasery, Anupama Shirali, Klaus Edvardsen, David J. Chaplin. United States Patent (US 7,456,214), issued November 25, 2008.

Combretastatin Analogs with Tubulin Binding Activity.
Kevin G. Pinney, Madhavi Sriram. United States Patent (US 7,429,681 B2), issued September 30, 2008.

Functionalized Stilbene Derivatives as Improved Vascular Targeting Agents.
Chaplin, David J.; Garner III, Charles Manly; Kane, Robert; Pinney, Kevin G.; Prezioso, Joseph Anthony; Edvardsen, Klaus. United States Patent (US 7,384,925), issued June 10, 2008.

Tubulin Binding Agents and Corresponding Prodrug Constructs.
Kevin G. Pinney, Vani P. Mocharla, Zhi Chen, Charles M. Garner, Mallinath Hadimani, Raymond Kessler, James M. Dorsey, Klaus Edvardsen, David J. Chaplin, Joseph Prezioso, Anjan Ghatak (Usha R. Ghatak). United States Patent (US 7,091,240), issued August 15, 2006.

Tubulin Binding Agents and Corresponding Prodrug Constructs.
Kevin G. Pinney, Vani P. Mocharla, Zhi Chen, Anjan Ghatak (Usha R. Ghatak), Mallinath Hadimani, Jimmy Kessler, James M. Dorsey, Klaus Edvardsen, David J. Chaplin, Joseph Prezioso. United States Patent (US 7,001,926 B2), issued February 21, 2006.

Compositions and Methods for Use in Targeting Vascular Destruction.
Ronald W. Pero, David Sherris, Kevin G. Pinney, Vani P. Mocharla, Zhi Chen. U.S. Patent Application (Serial No. 10/218,833), filed August 14, 2002. United States Patent (US 6,956,054), issued October 18, 2005.

Functionalized Stilbene Derivatives as Improved Vascular Targeting Agents.
David J. Chaplin, Charles Manly Garner III, Robert Ronald Kane, Kevin G. Pinney, Joseph Anthony Prezioso, and Klaus Edvardsen. United States Patent (US 6,919,324 B2), issued July 19, 2005.

Indole-Containing and Combretastatin-Related Anti-Mitotic and Anti-Tubulin Polymerization Agents.
Kevin G. Pinney, Feng Wang, and Mallinath Hadimani. Australian Patent Application (No. 2000074934), filed September 15, 2000. Australian Patent, issued February 17, 2005.

Indole-Containing and Combretastatin-Related Anti-Mitotic and Anti-Tubulin Polymerization Agents.
Kevin G. Pinney, Feng Wang, and Mallinath Hadimani. United States Patent (US 6,849,656 B1), issued February 1, 2005.

Anti-Mitotic Agents Which Inhibit Tubulin Polymerization. 
Kevin G. Pinney, Maria del Pilar Mejia, Vani P. Mocharla, Anupama Shirali, George R. Pettit. Australian Patent Application (No. 765418), issued January 15, 2004.

Tubulin Binding Ligands and Corresponding Prodrug Constructs.
Kevin G. Pinney, Vani P. Mocharla, Zhi Chen, Charles M. Garner, Anjan Ghatak, Jimmy Dorsey. U.S. Patent Application, filed on March 12, 2001. United States Patent (US 6,593,374), issued July 15, 2003.

Tubulin Binding Ligands and Corresponding Prodrug Constructs.
Kevin G. Pinney, Vani P. Mocharla, Zhi Chen, Charles M. Garner, Anjan Ghatak, Mallinath Hadimani, Jimmy Kessler, and Jimmy Dorsey. U.S. Patent Application, filed on March 12, 2001. United States Patent (US 6,593,374), issued July 15, 2003.

Anti-Mitotic Agents Which Inhibit Tubulin Polymerization. 
Kevin G. Pinney, Maria del Pilar Mejia, Vani P. Mocharla, Anupama Shirali, George R. Pettit. U.S. Patent (Serial No. US 6,350,777) based on PCT/US98/04380, issued February 26, 2002.

Anti-Mitotic Agents Which Inhibit Tubulin Polymerization.
Kevin G. Pinney, Maria del Pilar Mejia, Vani P. Mocharla, Anupama Shirali, George R. Pettit. Australian Patent Application (No. 732917) based on PCT/US98/04380, issued August 16, 2001.

Anti-Mitotic Agents Which Inhibit Tubulin Polymerization. 
Kevin G. Pinney, Pilar Mejia, Vani P. Mocharla, Anupama Shirali, George R. Pettit. U.S. Patent Application (Serial No. 06,162,930), based on PCT/US98/04380, issued December 19, 2000.

Anti-Mitotic Agents Which Inhibit Tubulin Polymerization. 
Kevin G. Pinney, Baylor University, Application for United States Letters Patent, filed March 6, 1997. United States Patent (US 5,886,025), issued, March 23, 1999.

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Publications prior to Baylor University

Stereoselective Synthesis of 2,5-Dihydrofurans by Sequential S_N2’ Cleavage of Alkynyloxiranes and Ag⁺-Catalyzed Cyclization of the Allenylcarbinol Products
Marshall, J. A.; Pinney, K. G. J. Org. Chem. 58: 7180-7184, 1993.

Structural and Computational Modeling Studies on 3-Aroyl-2-arylbenzo[b]thiophene Estrogen Receptor Ligands: LY117018 and Aryl Azide Photoaffinity Labeling Analogs; Investigation of Conformational Preferences, Differential Photoreactivity, and Preferential Modes of Binding
Kym, P.R.; Anstead, G. M.; Pinney, K. G.; Wilson, S. R.; Katzenellenbogen, J. A. J. Med. Chem. 36: 3910-3922, 1993.

Non-Steroidal Estrogens Bearing Acyl Azide Functions: Potential Electrophilic and Photoaffinity Labeling Agents for the Estrogen Receptor
Pinney, K. G.; Carlson, K. E.; Katzenellenbogen, J. A. Steroids 57: 222-232, 1992.

Synthesis of a Tetrafluoro-Substituted Aryl Azide and Its Protio Analogue as Photoaffinity Labeling Reagents for the Estrogen Receptor
Pinney, K. G.; Katzenellenbogen, J. A. J. Org. Chem. 56: 3125-3133, 1991.

Efficient and Selective Photoaffinity Labeling of the Estrogen Receptor Using Two Nonsteroidal Ligands That Embody Aryl Azide or Tetrafluoroaryl Azide Photoreactive Functions
Pinney, K. G.; Carlson, K. E.; Katzenellenbogen, B. S.; Katzenellenbogen, J. A. Biochemistry 30: 2421-2431, 1991.

Torsionally and Hydrophobically Modified 2,3-Diarylindenes as Estrogen Receptor Ligands
Anstead, G. M.; Peterson, C. S.; Pinney, K. G.; Wilson, S. R.; Katzenellenbogen, J. A. J. Med. Chem. 33: 2726-2734, 1990.

Target Tissue Uptake Selectivity of Three Fluorine-Substituted Progestins: Potential Imaging Agents for Receptor-Positive Breast Tumors
Pomper, M. G.; Pinney, K. G.; Carlson, K. E.; Mathias, C. J.; Welch, M. J.; Katzenellenbogen, J. A. Nucl. Med. Biol. (Int. J. Radiat. Appl. Instrum., Part B) 17: 309-319, 1990.

[³H]DU41165: A High Affinity Ligand and Novel Photoaffinity Labeling Reagent for the Progesterone Receptor
Pinney, K. G.; Carlson, K. E.; Katzenellenbogen, J. A. J. Steroid Biochem. 35(2): 179-189, 1990.

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