Imaging-Guided Evaluation of the Novel Small-Molecule Benzosuberene Tubulin-Binding Agent KGP265 as a Potential Therapeutic Agent for Cancer Treatment:Yihang Guo, Honghong Wang, Jeni L. Gerberich, Samuel O. Odutola, Amanda K. Charlton-Sevcik, Maoping Li, Rajendra P. Tanpure, Justin K. Tidmore, Mary Lynn Trawick, Kevin G. Pinney, Ralph P. Mason, Li Liu, Cancers, 2021, 13 (19), 4769. https://doi.org/10.3390/cancers13194769
Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors Li Liu, Devin O’Kelly, Regan Schuetze, Graham Carlson, Heling Zhou, Mary Lynn Trawick, Kevin G. Pinney, Ralph P. Mason, Molecules, 2021, 26, 2551. https://www.mdpi.com/1420-3049/26/9/2551
Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anti-Cancer Agents Targeted Towards Tumor-Associated Hypoxia: Blake A. Winn, Laxman Devkota, Bunnarack Kuch, Matthew T. MacDonough, Tracy E. Strecker, Yifan Wang, Zhe Shi, Jeni L. Gerberich, Deboprosad Mondal, Alejandro J. Ramirez, Ernest Hamel, David J. Chaplin, Peter Davis, Ralph P. Mason, Mary Lynn Trawick, Kevin G. Pinney, Journal of Natural Products, 2020, 83, 4, 937-954. https://doi.org/10.1021/acs.jnatprod.9b00773
Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization: Haichan Niu, Tracy E. Strecker, Jeni L. Gerberich, James W. Campbell III, Debabrata Saha, Deboprosad Mondal, Ernest Hamel, David J. Chaplin, Ralph P. Mason, Mary Lynn Trawick, and Kevin G. Pinney, Journal of Medicinal Chemistry, 2019. https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00551
Synthesis of Dihydronaphthalene Analogues Inspired by Combretastatin A-4 and their Biological Evaluation Casey J. Maguire, Zhi Chen, Vani P. Mocharla, Madhavi Sriram, Tracy E. Strecker, Ernest Hamel, Heling Zhou, Ramona Lopez, Yifan Wang, Ralph P. Mason, David J. Chaplin, Mary Lynn Trawick, Kevin G. Pinney, Med. Chem. Commun., 2018, 9, 1649-1662. https://pubs.rsc.org/en/content/articlelanding/2018/md/c8md00322j#!divAbstract
Synthesis and Biological Evaluation of a Water-Soluble Phosphate Prodrug Salt and Structural Analogues of KGP94, a Lead Inhibitor of Cathepsin L Erica N. Parker, Samuel O. Odutola, Yifan Wang, Tracy E. Strecker, Rajeswari Mukherjee, Zhe Shi, David J. Chaplin, Mary Lynn Trawick, Kevin G. Pinney, Bioorganic and Medicinal Chemistry Letters, 2017, 27, 1304-1310. http://dx.doi.org/10.1016/j.bmcl.2016.12.039
Bioreductively Activatable Prodrug Conjugates of Phenstatin Designed to Target Tumor Hypoxia Blake A. Winn, Zhe Shi, Graham J. Carlson, Yifan Wang, Benson L. Nguyen, Evan M. Kelly, R. David Ross IV, Ernest Hamel, David J. Chaplin, Mary Lynn Trawick, Kevin G. Pinney, Bioorganic and Medicinal Chemistry Letters, 2017, 27, 636-641. http://dx.doi.org/10.1016/j.bmcl.2016.11.093
Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization Christine A. Herdman, Tracy E. Strecker, Rajendra P. Tanpure, Zhi Chen, Alex Winters, Jeni Gerberich, Li Liu, Ernest Hamel, Ralph P. Mason, David J. Chaplin, Mary Lynn Trawick, Kevin G. Pinney, Med. Chem. Commun.,2016, 7, 2418 – 2427.DOI: 10.1039/C6MD00459H
Design, Synthesis, and Biological Evaluation of Water-Soluble Amino Acid Prodrug Conjugates Derived from Combretastatin, Dihydronaphthalene, and Benzosuberene-Based Parent Vascular Disrupting Agents Laxman Devkota, Chen-Ming Lin, Tracy E. Strecker, Yifan Wang, Justin K. Tidmore, Zhi Chen, Rajsekhar Guddneppanavar, Christopher J. Jelinek, Ramona Lopez, Li Liu, Ernest Hamel, Ralph P. Mason, David J. Chaplin, Mary Lynn Trawick, Kevin G. Pinney, Bioorganic and Medicinal Chemistry, 2016, 24, 938-956 http://dx.doi.org/10.1016/j.bmc.2016.01.007
Structural Interrogation of Benzosuberene-based Inhibitors of Tubulin Polymerization Christine A. Herdman, Laxman Devkota, Chen-Ming Lin, Haichan Niu, Tracy E. Strecker, Ramona Lopez, Li Liu, Clinton S. George, Rajendra P. Tanpure, Ernest Hamel, David J. Chaplin, Ralph P. Mason, Mary Lynn Trawick, Kevin G. Pinney, Bioorganic and Medicinal Chemistry, 2015,23, 7497-7520. https://www.sciencedirect.com/science/article/pii/S0968089615300900
Synthesis and Biochemical Evaluation of Benzoylbenzophenone Thiosemicarbazone Analogues as Potent and Selective Inhibitors of Cathepsin L. Erica N. Parker, Jiangli Song, G. D. Kishore Kumar, Samuel O. Odutola, Gustavo E. Chavarria, Amanda K. Charlton-Sevcik, Tracy E. Strecker, Ashleigh L. Barnes, Dhivya R. Sudhan, Thomas R. Wittenborn, Dietmar W. Siemann, Michael R. Horsman, David J. Chaplin, Mary Lynn Trawick, Kevin G. Pinney, Bioorganic and Medicinal Chemistry, 2015, 23, 6974. https://www.sciencedirect.com/science/article/pii/S0968089615300614?via%3Dihub
The Vascular Disrupting Activity of OXi8006 in Endothelial Cells and Its Phosphate Prodrug OXi8007 in Breast Tumor Xenografts. Tracy E. Strecker, Samuel O. Odutola, Ramona Lopez, Morgan S. Cooper, Justin K. Tidmore, Amanda K. Charlton-Sevcik, Li Li, Matthew T. MacDonough, Mallinath B. Hadimani, Anjan Ghatak, Li Liu, David J. Chaplin, Ralph P. Mason, Kevin G. Pinney, and Mary Lynn Trawick, Cancer Letters, 2015, accepted, in press, doi: 10.1016/j.canlet.2015.08.021 https://www.sciencedirect.com/science/article/pii/S0304383515005613?via%3Dihub
Evaluation of tumor ischemia in response to an indole-based vascular disrupting agent using BLI and 19F MRI. Heling Zhou, Rami R. Hallac, Ramona Lopez, Rebecca Denney, Matthew T. MacDonough, Li Li, Li Liu, Edward E. Graves, Mary Lynn Trawick, Kevin G. Pinney, and Ralph P. Mason, American Journal of Nuclear Medicine and Molecular Imaging, 2015, 5(2), 143-153. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396009/
Synthesis of Structurally Diverse Benzosuberene Analogues and their Biological Evaluation as Anti-cancer Agents. Tanpure, R. P.; George, C. S.; Strecker, T. E.; Devkota, L.; Tidmore, J. K.; Lin, C.-M.; Herdman, C. A.; MacDonough, M. T.; Sriram, M.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorganic and Medicinal Chemistry, 21, 8019-8032, 2013. https://www.sciencedirect.com/science/article/pii/S0968089613007293?via%3Dihub
Synthesis of 2-Aryl-3-Aroyl-Indole Salt (OXi8007) Resembling Combretastatin A-4 with Application as a Vascular Disrupting Agent. Hadimani, M. B.; MacDonough, M. T.; Ghatak, A.; Strecker, T. E.; Lopez, R.; Sriram, M.; Nguyen, B. L.; Hall, J. J.; Kessler, R. J.; Shirali, A. R.; Liu, L.; Garner, C. M.; Pettit, G. R.; Hamel, E.; Chaplin, D. J.; Mason, R. P.; Trawick, M. L.; Pinney, K. G. Journal of Natural Products, 76, 1668-1678, 2013. https://pubs.acs.org/doi/10.1021/np400374w
Synthesis and Biological Evaluation of Indole-based, Anti-cancer Agents Inspired by the Vascular Disrupting Agent 2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006). MacDonough, M. T.; Strecker, T. E.; Hamel, E.; Hall, J. J.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G.Bioorganic and Medicinal Chemistry, 21, 6831-6843, 2013. https://www.sciencedirect.com/science/article/pii/S0968089613006482
Small-Molecule Inhibitors of Cathepsin L Incorporating Functionalized Ring-Fused Molecular Frameworks. Song, J.; Jones, L. M.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Jantz, A.; Johansen, A.; Bayeh, L.; Soeung, V.; Snyder, L. K.; Lade, Jr., S. D.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorganic Medicinal Chemistry Letters, 23: 2801-2807, 2013. https://www.sciencedirect.com/science/article/pii/S0960894X12016095
Initial Evaluation of the Antitumour Activity of KGP94, a Functionalized Benzophenone Thiosemicarbazone Inhibitor of Cathepsin L. Chavarria, G. E.; Horsman, M. R.; Arispe, W. M.; Kumar, G. D. K.; Chen, S.-E.; Strecker, T. E.; Parker, E. N.; Chaplin, D. J.; Pinney, K. G.; Trawick, M. L. European Journal of Medicinal Chemistry, 58: 568-572,2012. https://www.sciencedirect.com/science/article/pii/S0223523412006435
Synthesis and Biochemical Evaluation of Thiochromanone Thiosemicarbazone Analogues as Inhibitors of Cathepsin L. Song, J.; Jones, L. M.; Kumar, G. D. K.; Conner, E. S.; Bayeh, L.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Chen, S.-E.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. ACS Medicinal Chemistry Letters, 3: 450-453,2012. https://pubs.acs.org/doi/abs/10.1021/ml200299g
An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity. *Tanpure, R. P.; *George, C. S.; *Sriram, M.; Strecker, T. E.; Tidmore, J. K.; Hamel, E.; Charlton-Sevcik, A. K.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. MedChemComm, 3: 720-724, 2012. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682772/
[* denotes authors with equal contributions]
Regioselective Synthesis of Water Soluble Monophosphate Derivatives of Combretastatin A-1. Tanpure, R. P.; Nguyen, B. L.; Strecker, T. E.; Aguirre, S.; Sharma, S.; Chaplin, D. J.; Siim, B. G.; Hamel, E.; Lippert, J. W. III; Pettit, G. R.; Trawick, M. L.; Pinney, K. G. Journal of Natural Products 74: 1568-1574,2011. https://pubs.acs.org/doi/abs/10.1021/np200104t
A Perspective on Vascular Disrupting Agents that Interact with Tubulin: Preclinical Tumor Imaging and Biological Assessment. Mason, R. P.; Zhao, D.; Liu, L.; Trawick, M. L.; Pinney, K. G. Integr. Biol. 3: 375-387, 2011. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071431/
(Invited contribution to honor Professor Mina J. Bissell for her lifetime contributions to the tumor microenvironment and research involving the extracellular matrix)
Functionalized Benzophenone, Thiophene, Pyridine, and Fluorene Thiosemicarbazone Derivatives as Inhibitors of Cathepsin L . Kumar, G. D. K.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Yoo, G. K.; Song, J.; Strecker, T. E.; Siim, B. G.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. Lett. 20: 6610-6615, 2010. https://www.sciencedirect.com/science/article/pii/S0960894X1001317X
Regio- and Stereospecific Synthesis of Mono ß-D-Glucuronic Acid Derivatives of Combretastatin A-1. Tanpure, R. P.; Strecker, T. E.; Chaplin, D. J.; Siim, B. G.; Trawick, M. L.; Pinney, K. G. J. Nat. Prod. 73: 1093-1101, 2010. https://pubs.acs.org/doi/abs/10.1021/np100108e
Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Kumar, G. D. K.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Arispe, W. M.; MacDonough, M. T.; Strecker, T. E.; Chen, S.-E.; Siim, B. G.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. Lett. 20: 1415-1419, 2010. https://www.sciencedirect.com/science/article/pii/S0960894X09018137
Application of the McMurry Coupling Reaction in the Synthesis of Tri- and Tetra-arylethylene Analogues as Potential Cancer Chemotherapeutic Agents. Tanpure, R. P.; Harkrider, A. R.; Strecker, T. E.; Hamel, E.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. 17: 6993-7001, 2009. https://www.sciencedirect.com/science/article/pii/S0968089609007615
Design, Synthesis and Biological Evaluation of Dihydronaphthalene and Benzosuberene Analogs of the Combretastatins as Inhibitors of Tubulin Polymerization in Cancer Chemotherapy. Sriram, M.; Hall, J. J.; Grohmann, N. C.; Strecker, T. E.; Wootton, T.; Franken, A.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. 16: 8161-8171, 2008. https://www.sciencedirect.com/science/article/pii/S0968089608006639
Design, Synthesis, Biochemical, and Biological Evaluation of Nitrogen-Containing Triflouro Structural Modifications of Combretastatin A-4. Hall, J. J.; Sriram, M.; Strecker, T. E.; Tidmore, J. K.; Jelinek, C. J.; Kumar, G. D. K.; Hadimani, M. B.; Pettit, G. R.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. Lett. 18: 5146-5149, 2008. https://www.sciencedirect.com/science/article/pii/S0960894X08008330
Combretastatin Dinitrogen-Substituted Stilbene Analogues as Tubulin-Binding and Vascular-Disrupting Agents. Siles, R.; Ackley, J. F.; Hadimani, M. B.; Hall, J. J.; Mugabe, B. E.; Guddneppanavar, R.; Monk, K. A.; Chapuis, J.-C.; Pettit, G. R.; Chaplin, D. J.; Edvardsen, K.; Trawick, M. L.; Garner, C. M.; Pinney, K. G. J. Nat. Prod. 71: 313-320, 2008. https://pubs.acs.org/doi/abs/10.1021/np070377j
Design, Synthesis and Biochemical Evaluation of Novel Cruzain Inhibitors with Potential Application in the Treatment of Chagas’ Disease. Siles, R.; Chen, S.-E.; Zhou, M.; Pinney, K. G.; Trawick, M. L. Bioorg. Med. Chem. Lett. 16: 4405-4409,2006. https://www.sciencedirect.com/science/article/pii/S0960894X0600583X
Design, Synthesis, and Biological Evaluation of Combretastatin Nitrogen-Containing Derivatives as Inhibitors of Tubulin Assembly and Vascular Disrupting Agents. Monk, K. A.; Siles, R.; Hadimani, M. B.; Mugabe, B. E.; Ackley, J. F.; Studerus, S. W.; Edvardsen, K.; Trawick, M. L.; Garner, C. M.; Rhodes, M. R.; Pettit, G. R.; Pinney, K. G. Bioorg. Med. Chem. 14: 3231-3244, 2006. https://www.sciencedirect.com/science/article/pii/S0968089605012198?via%3Dihub
X-ray crystal structure of 2,5-dioxo-4-imidazolidineethanesulfonamide, C5H9N3O4S
Kautz, J. A.; Chang, C.; Qin, C.; Trawick, M. L.; J. Chem. Crystallogr. 33: 277, 2003.
Spectrophotometric Assays for L-Lysine α-Oxidase and γ-Glutamylamine Cyclotransferase
Danson, J. W.; Trawick, M. L.; Cooper, A. J. L. Analyt. Biochem. 303: 120-130, 2002.
Abstracts
Kinetic Analysis and Antitumor Activity of Thiosemicarbazone Benzophenone Inhibitors of cathepsin L
Chavarria, G. E.; Strecker, T. E.; Kumar, G. D. K.; Jones, L. M.; Chaplin, D. J.; Pinney, K. G.; Trawick, M. L.; FASEB J March 29, 2012 26:962.7
Study of a Potent Small-Molecule Benzosuberene Anti-Cancer Agent
Charlton-Sevcik, A. K.; Strecker, T. E.; Odutola, S. O.; Tidmore, J. K.; Tanpure, R. P.; George, C.; Sriram, M.; Chaplin, D. J.; Pinney, K. G.; Trawick, M. L.; FASEB J March 29, 2012 26:613.5
The effect of benzosuberene analogues on endothelial cell morphology and tube formation
Tidmore, J. K.; Strecker, T. E.; Odutola, S. O.; Charlton-Sevcik, A. K.; Tanpure, R. P.; George, C.; Sriram, M.; Chaplin, D. J.; Pinney, K. G.; Trawick, M. L.; FASEB J March 29, 2012 26:999.8
ASBMB National Meeting April 2012 of Antivascular Effects of KGP265 in Breast Cancer using Dynamic Bioluminescence
Magnusson, J.; Trawick, M. L.; Pinney, K. G.; Mason, R. P.; Liu, L.; Innovations in Cancer Prevention and Research Conference, Cancer Prevention and Research Institute of Texas (CPRIT), Abstract No. 159, November 15-17, 2011, Austin, Texas.
Highly Potent Small-Molecule Benzosuberene Anti-Cancer Agents
Pinney, K. G.; Trawick, M. L.; Strecker, T. E.; Charlton-Sevcik, A. K.; Odutola, S.; Tidmore, J.; Tanpure, R. P.; George, C.; Sriram, M.; Liu, L.; Mason, R. P.; Chaplin, D. J.; Innovations in Cancer Prevention and Research Conference, Cancer Prevention and Research Institute of Texas (CPRIT), Abstract No. 211, November 15-17, 2011, Austin, Texas.
Biochemical and Biological Evaluation of Tubulin-Binding Vascular Disrupting Agents
Trawick, M. L.; Pinney, K. G.; Liu, L.; Mason, R. P.; Abstract No: 288, 67th Southwest Regional Meeting (SWRM) of the American Chemical Society (ACS), November 9-12, 2011, Austin, TX (invited oral presentation by Mary Lynn on Thursday November 10, 2011).
Discovery and Development of Small-Molecule Vascular Disrupting Agents
Pinney, K. G.; Trawick, M. L.; Abstract No: 287, 67th Southwest Regional Meeting (SWRM) of the American Chemical Society (ACS), November 9-12, 2011, Austin, TX (invited oral presentation by Kevin on Thursday November 10, 2011).
Thiosemicarbazones as Low Nanomolar Thiosemicarbazone Inhibitors of Cruzain
Chavarria, G. E.; Soeung, M.; Guillory, J. D.; Kumar, G. D. K.; Arispe, W. M.; Adamson, L. J.; Yoo, G. K.; Song, J.; Pinney, K. G.; Trawick, M. L.; Abstract No: 203, 67th Southwest Regional Meeting (SWRM) of the American Chemical Society (ACS), November 9-12, 2011, Austin, TX (oral presentation by Gustavo on Wednesday November 9, 2011).
Advanced Kinetic Studies of Non-Peptidic, Small Molecule Thiosemicarbazone Inhibitors of Cathepsin B
Charlton-Sevcik, A. K.; Synder, L. K.; Soeung, V.; Jones, L. M.; Kumar, G. D. K.; Chaplin, D. J.; Pinney, K. G.; Trawick, M. L.; Abstract No: 102, 67th Southwest Regional Meeting (SWRM) of the American Chemical Society (ACS), November 9-12, 2011, Austin, TX (poster presented by Amanda on Wednesday November 9, 2011).
Development and Initial Evaluation of the Antitumor Activity of a Functionalized Benzophenone Thiosemicarbazone Inhibitor of Cathepsin L
Trawick, M. L.; Pinney, K. G.; Chaplin, D. J.; Horsman, M. R.; Chavarria, G. E.; Arispe, W. M.; Kumar, G. D. K.; Abstract No. 1416, American Association of Cancer Research (AACR) 102nd Annual Meeting, April 2-6, 2011. Poster presented on April 4, 2011.
Analysis of Novel Thiosemicarbazone Inhibitors of Cathepsin B
Charlton-Sevcik, A. K.; Synder, L. K.; Soeung, V.; Wheeler, K. M.; Song, J.; Jones, L. M.; Kumar, G. D. K.; Trawick, M. L.; Siim, B. G.; Chaplin, D. J.; Pinney, K. G.; Chen, S.-E.; MacDonough, M. T.; Yoo, G. K.; Locke, A.; Abstract No: BIOL: 110, 241st ACS National Meeting & Exposition, March 27-31, 2011, Anaheim, CA (poster presented on Tuesday March 29, 2011).
Thiosemicarbazones as Potent and Selective Cathepsin K Inhibitors
Chavarria, G. E.; Kumar, G. D. K.; Jones, L. M.; MacDonough, M. T.; Yoo, G. K.; Locke, A.; Deliz, R.; Chaplin, D. J.; Siim, B. G.; Chen, S.-E.; Pinney, K. G.; Trawick, M. L.; Abstract No: BIOL: 111, 241st ACS National Meeting & Exposition, March 27-31, 2011, Anaheim, CA (poster presented on Tuesday March 29, 2011).
Analysis of novel low nanomolar thiosemicarbazone inhibitors of cruzain.
Chavarria, G. E.; Wiley, J. A.; Kumar, G. D. K.; Arispe, W. M.; Li, W.; Adamson, L. J.; Jones, L. M.; MacDonough, M. T.; Pinney, K. G.; Trawick, M. L. FASEB J. 24: 681.5, 2010.
Kinetics of Thiosemicarbazone-Based Inhibitors of Cathepsin L
Trawick, M. L.; Arispe, W. M.; Chen, S. E.; Siles, R.; Zhou, M.; Pinney, K. G. FASEB J. 21: A642, 2007.
Kinetic Studies of Potent Thiosemicarbazone Inhibitors of Cruzain
Chen, S.-E.; Siles, R.; Zhou, M.; Arispe, W. M.; Lee, H.; Pinney, K. G.; Trawick, M. L. FASEB J. 21: A641, 2007.
Biological Evaluation of Mono and Dichloro-Substituted Conbretastatin Analogs as Inhibitors of Tubulin Polymerization
Mugabe, B. E.; Trawick, M. L.; Monk, K. A.; Siles, R.; Mallinath, B. H.; Garner, C. M.; Kane, R. R.; Pinney, K. G. FASEB J. 19: A276, 2005.
Characterizing the Enzyme that Catalyzes the Catabolism of Nε-(L-γ-Glutamyl)-L-lysine
Gonzalez, F.; Chen, S. E.; Trawick, M. L. FASEB J. 19: A860, 2005.
Analogs of Combretastatin A-1 and A-4 as Tumor Vascular Targeting Agents
Trawick, M. L.; Mugabe, B. E.; Monk, K. A.; Garner, C. M.; Pinney, K. G.; Siles, R.; Arthasery, P. FASEB J. 18: C230, 2004.
Evaluation of Synthetic Analogs of Combretastatin A1 and A4 as Inhibitors of Tubulin Assembly
Trawick, M. L.; Studerus, S. W.; Mugabe, B. E.; Garner, C. M.; Kane, R. R.; Monk, K. A.; Pinney, K. G.; Siles, R.; Zhang, J. FASEB J. 17: A1314,2003.
Book Chapters
Pinney, K. G.; Pettit, G. R.; Trawick, M. L.; Jelinek, C.; Chaplin, D. J. The Discovery and Development of the Combretastatins. In Antitumor Agents from Natural Products, 2nd Edition, D. Kingston, D. Newman, and G. Cragg, eds. Boca Raton, FL: CRC Press, Taylor and Francis Group,Submitted March 6, 2010; Accepted June 22, 2010; (2011, in press).
Meetings
Patents
David J. Chaplin, Kishore Kumar Gaddale Devanna, Erica Parker, Kevin G. Pinney, Jiangli Song, Mary Lynn Trawick, “Compositions and Methods for Inhibition of Cathepsins” (United States Patent: US 9,873,668), issued January 23, 2018.
Compositions and Methods for Inhibition of Cathepsins
David J. Chaplin, Kishore Kumar Gaddale Devanna, Erica Parker, Kevin G. Pinney, Jiangli Song, Mary Lynn Trawick. (United States Patent: US 9,458,103), issued October 4, 2016.
Compositions and Methods for Inhibition of Cathepsins
David J. Chaplin, Kishore Kumar Gaddale Devanna, Erica Parker, Kevin G. Pinney, Jiangli Song, Mary Lynn Trawick. (United States Patent: US 8,877,967 B2), issued November 4, 2014.
Undergraduate Work
Victoria Soeung (Mentor, Mary Lynn Trawick, Chemistry and Biochemistry)
Title: Advanced Kinetic Studies of Cathepsin B Inhibitors Sharing a Thiosemicarbazone Moiety
(Co-Authors: Lindsey K. Snyder, Amanda K. Charlton-Sevcik, G. D. Kishore Kumar, Lindsay M. Jones, Kevin G. Pinney, and Mary Lynn Trawick), Dallas-Fort Worth American Chemical Society Meeting, 44th Meeting-in-Miniature, Tarleton State University, Stephenville, Texas, April 16, 2011.
Lindsey K. Snyder (Mentor, Mary Lynn Trawick, Chemistry and Biochemistry) – Won 2nd place prize.
Title: Fluorometric Analysis of Novel Thiosemicarbazone Inhibitors of Cathepsin B
(Co-Authors: Victoria Soeung, Amanda K. Charlton-Sevcik, G. D. Kishore Kumar, Lindsay M. Jones, Kevin G. Pinney, and Mary Lynn Trawick), Dallas-Fort Worth American Chemical Society Meeting, 44th Meeting-in-Miniature, Tarleton State University, Stephenville, Texas, April 16, 2011.
Melinda Soeung (Mentor, Mary Lynn Trawick, Chemistry and Biochemistry)
Title: Structure-Activity Relationship of Novel Low Nanomolar Thiosemicarbazone Inhibitors of Cruzain
(Co-Authors: Gustavo E. Chavarria, Jacob A. Wiley, Kishore Kumar Gaddale Devanna, Wara M. Arispe, Weiyue Li, Lauren J. Adamson, Lindsay M. Jones, Matthew T. MacDonough, Kevin G. Pinney, and Mary Lynn Trawick), Dallas-Fort Worth American Chemical Society Meeting, 44th Meeting-in-Miniature, Tarleton State University, Stephenville, Texas, April 16, 2011.
URSA POSTER 2012 Biochemical Evaluation and Molecular Modeling of Thiosemicarbazone Inhibitors of Cruzain
Joe Guillory, Jay Johnson, Gustavo Chavarria, G.D. Kishore Kumar , Kevin G. Pinney, and Mary Lynn TrawickBiochemical Evaluation of Thiosemicarbazone Compounds for the Treatment of Chagas’ Disease
Victoria Soeung, Amanda Charlton-Sevcik, Jiangli Song, Gustavo Edgardo Chavarria, Kevin G. Pinney, and Mary Lynn TrawickHPLC Analysis of the Enzymatic Bioreductive Cleavage of Prodrugs
Morgan S. Cooper, Gustavo E. Chavarria, Rajendra P. Tanpure, Clinton George, David J. Chaplin, Kevin G. Pinney, and Mary Lynn Trawick
