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Symposium Schedule

Monday AM (BSB E.125)
8:50-9:00 AM               Introduction/Welcome, Patrick Farmer
Session 1 – “Multicomponent Reactions” Session Chair – Pat Farmer
9:00 -9:30 AM             Dr. Michael Trakselis (Baylor) “A Supraholoenzyme DNA Polymerase Complex Couples High Fidelity and Translesion Syntheses”
9:30-10:00 AM            Dr. Jung-Hyun Min (U. Illinois Chicago) “Structure and dynamics of DNA damage recognition during eukaryotic nucleotide excision repair”
10:00-10:30 AM           Dr. Elyssia Gallagher (Baylor) “Characterizing Conformational Changes in Human Phosphatase PP2Cα and a Catalytically Inactive Metal Binding Site Mutant by Hydrogen/Deuterium Exchange – Mass Spectrometry”

10:30-10:45 AM           Break (Coffee Break)
 
Session 2 – “DNA Topology” – Session Chair – Ilya Finkelstein
10:45-11:15 AM           Dr. David Bates (Baylor College of Medicine) “DNA topology-mediated replication fork pausing and reversal at protein barriers”
11:15-11:45 AM           Dr. Lynn Zechiedrich (Baylor College of Medicine) “Structural diversity of supercoiled DNA”
11:45 -12:15 PM          Dr. Karen Vasquez (UT Austin) “DNA Structure-induced genetic instability and cancer”
12:15-1:30 PM             Lunch – Catered to all participants (BSB Atrium)

Monday PM (BSB E.125)
Session 3 – “Repair Polymerases”, Session Chair – Michael Trakselis
1:30-2:00 PM               Dr. Rick Wood (MD Anderson) “Specialized DNA polymerases and cellular viability”
2:00-2:30 PM               Dr. Seongmin Lee (UT Austin) “Alkylation damage and replication fidelity”
2:30-3:30 PM               Dr. Fred Guengerich (Vanderbilt University) “How translesion DNA polymerases do right and wrong pairing with modified bases: Structural and functional studies”
3:30 -5:30 PM              Poster Session (2nd Floor Balcony)

Tuesday AM (BSB E.125)
Session 4 – “Inhibition”, Session Chair – David Bates
8:30-9:00 AM              Dr. Ken Johnson (UT Austin) “Allosteric Inhibition of Hepatitis C Viral RNA-dependent RNA Polymerase by Non-nucleoside Inhibitors”
9:00-9:30 AM               Dr. Mary Lynn Trawick (Baylor) “Mechanism of Action of Tubulin-binding Vascular Disrupting Anti-cancer Agents”
9:30-10:00 AM             Dr. Larry Sowers (UTMB) “Why are some halogenated pyrimidines mutagenic?”
10:00-10:15 AM           Break (Coffee Break)

Session 5 – “RNA Components”, Session Chair – Jung-Hyun Min
10:15-10:45 AM           Dr. Ilya Finkelstein (UT Austin) “Hijacking next-generation sequencing for quantitative studies of CRISPR interference.”
10:45-11:15 AM           Dr. Craig Kaplan (TAMU) “Mechanism and Regulation of RNA Polymerase II”
11:15-11:45 AM          Dr. Dorothy Shippen (TAMU) “Arabidopsis telomerase: Evolving new subunits for an old enzyme”

11:45-12:00 AM           Closing Remarks