Pateamine A is a marine sponge-derived natural product that stabilizes human eukaryotic initiation factor 4A (eIF4A) onto mRNA. This ‘clamping’ results in translation inhibition and has expressed anti-cancer effects in vivo on pancreatic cancer and chronic lymphocytic leukemia cell lines. We are using Molecular Operating Environment (MOE) software to propose and dock novel derivatives which exhibit better mRNA selectivity, higher potency, and lower lipophilicity. Derivatives with favorable characteristics will be synthesized and tested for activity and selectivity.