Publications

Research Articles

Hwa LS, Neira S, Flanigan ME, Stanhope CM, Pina MM, Pati D, Hon OJ, Yu W, Kokush E, Calloway RN, Boyt K, Kash TL. (2020). Alcohol Drinking Alters Stress Response to Predator Odor via Extended Amygdala Kappa Opioid Receptor Signaling in Male Mice. eLife 9;e59709. PDF eLife Digest

Pina MM, Pati D, Hwa LS, Wu SY, Mahoney AA, Omenyi CG, Navarro M, Kash TL. (2020). The kappa opioid receptor modulates GABA neuron excitability and synaptic transmission in midbrain-projections from the insular cortex. Neuropharmacology 165: 107831. PDF

Hwa LS, Neira S, Pina MM, Pati D, Calloway R, Kash TL. (2019) Predator Odor Increases Avoidance and Glutamatergic Synaptic Transmission in the Prelimbic Cortex via Corticotropin-Releasing Factor 1 signaling. Neuropsychopharmacology 44(4): 766-775. PDF

Yu W, Hwa LS, Makhijani V, Besheer J, Kash TL. (2019) Chronic inflammatory pain drives alcohol drinking in a sex-dependent manner for C57BL/6J mice. Alcohol 77:135-145. PDF

Newman EL, Albrechet-Souza L, Andrew PM, Auld JG, Burk KC, Hwa LS, Zhang EY, DeBold JF, Miczek KA (2018) Persistent escalation of alcohol consumption by mice exposed to brief episodes of social defeat stress: suppression by CRF-R1 antagonism. Psychopharmacology 235(6):1807-1820. PDF

Neiderkoffler V, Asher TE, Okaty BW, Rood BD, Narayan A, Hwa LS, Beck SG, Miczek KA, Dymecki SM. (2016) Identification of serotonergic neuronal modules that affect aggressive behavior. Cell Reports 17:1934-1949. PDF

Hardaway JA, Jensen J, Kim M, Mazzone CM, Sugam JA, Diberto JF, Lowery-Gionta EG, Hwa LS, Pleil KE, Bulik CM, Kash TL (2016) Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating. Behavioral Brain Research 307:25-34. PDF

Hwa LS, Holly EN, DeBold JF, Miczek KA (2016) Social stress-escalated intermittent alcohol dinking: modulation by CRF-R1 in the ventral tegmental area and accumbal dopamine in mice. Psychopharmacology 233(4): 681-690. PDF

Hwa LS, Shimamoto A, Norman KJ, Kayyali T, Valentino RJ, DeBold JF, Miczek KA (2016) Dissociation of mu opioid receptor and CRF-R1 antagonist effects on escalated ethanol consumption and mPFC serotonin in C57BL/6J mice. Addiction Biology 21(1):111-24. PDF

Newman EL, Smith KS, Takahashi A, Chu A, Hwa LS, Chen Y, DeBold JF, Rudolph U, Miczek KA (2015) α2-containing GABA(A) receptors: A requirement for midazolam-escalated aggression and social approach in mice. Psychopharmacology, 232(23): 4359-69. PDF

Albrechet-Souza L, Hwa LS, Han X, Zhang E, DeBold J, Miczek KA (2015) CRF binding protein and CRF2 receptors in the ventral tegmental area: modulation of ethanol binge drinking in C57BL/6J mice. Alcoholism: Clinical and Experimental Research 39(9): 1609-18. PDF

Hwa LS, Nathanson AJ, Shimamoto A, Tayeh J, Wilens AR, Holly EN, Newman EL, DeBold JF, Miczek KA (2015) Aggression and increased glutamate in the mPFC during withdrawal from intermittent alcohol in outbred mice. Psychopharmacology, 232(16): 2889-2902. PDF

Norman KJ, Seiden JA, Kickstein JA, Han X, Hwa LS, DeBold JF, Miczek KA (2015). Social Stress and Escalated Drug Self-Administration in Mice. I. Alcohol and Corticosterone. Psychopharmacology 232, 991-1001. PDF

Quadros IM, Hwa LS, Shimamoto A, Carlson JM, DeBold JF, Miczek KA (2014). Prevention of alcohol-heightened aggression by CRF-R1 antagonists in mice: critical role for DRN-PFC serotonin pathway. Neuropsychopharmacology 39: 2874-2883. PDF

Hwa LS, Kalinichev M, Haddouk H, Poli S, Miczek KA (2014). Reduction of excessive alcohol drinking by a novel GABAB receptor positive allosteric modulator ADX71441 in mice. Psychopharmacology 231: 333-343. PDF

Hwa LS, DeBold JF, Miczek KA (2013). Alcohol in excess: CRF1 receptors in the VTA and DRN. Psychopharmacology 225: 313-327. PDF

Hwa LS, Chu A, Levinson SA, Kayyali TK, DeBold JF, Miczek KA (2011). Persistent escalation of alcohol drinking in C57BL/6J mice with intermittent access to 20% ethanol. Alcoholism: Clinical and Experimental Research 35(11): 1938-1947. PDF

Scholarly Reviews

Farokhnia M, Berger AL, Karoly HC, Hwa LS, Varodayan FP (2020) The Promise of Neuroimmune Targets for Treating Drug Addiction and Other Psychiatric Disorders: Granulocyte-Colony Stimulating Factor Exemplification. Frontiers in Psychiatry 11:220. PDF

Hwa L, Besheer J, Kash T (2017) Glutamate plasticity woven through the progression to alcohol use disorder: a multi-circuit perspective. F1000Research, 6:298. PDF

Miczek KA, DeBold JF, Hwa LS, Newman EL, de Almeida RMM (2015). Alcohol and violence: neuropeptidergic modulation of monoamine systems. Annals of the New York Academy of Sciences, 1349: 96-118. PDF

Miczek KA, Takahashi A, Gobrogge KL, Hwa LS, De Almeida R (2015) Escalated aggression in animal models: shedding new light on mesocorticolimbic circuits. Current Opinion in Behavioral Science 3: 90-95. PDF