Selected Publications

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Taube JH*#, Sphyris N*, Johnson K, Reisenauer K, Nesbit TA, Joseph R, Vijay GV, Sarkar TR, Bhangre NA, Song JJ, Chang JT, Lee MG, Soundararajan R, Mani SA#. *co-first authors #co-corresponding authors The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transitionOncotarget, accepted (2017). Demonstrates a novel role for KDM6A in reversible EMT. Bold indicates Baylor-based co-authors. [link]

Sidjui L, Eyong K, Hull K, Folefoc G, Leddet V, Herbette G, Ollivier E, Taube J, Klausmeyer K, Romo D. Bioactive Lanostane-Type Triterpenoids from the Root of Leplaea Mayombensis (Meliaceae). Journal of Natural Products, in press (2017)

Eyong K, Bairy G, Eno A, Taube J,  Hull K, Folefoc G, Foyet H, Romo D. Triterpenoids from the stem bark of Vitellaria paradoxa (Sapotaceae) and derived esters exhibit cytotoxicity against a breast cancer cell line. Medicinal Chemistry Research, 14 September (2017)

Hodges S, Nolan S, Taube J, Lugo J. Adult Fmr1 knockout mice present with deficiencies in hippocampal IL-6 and TNFα expression. Neuroreport, in press (2017)


Werden SJ, Sphyris N, Sarkar TR, Paranjape AN, LaBaff AM, Taube JH, Hollier BG, Ramirez-Peña EQ, Soundararajan R, den Hollander P, Powell E, Echeverria GV, Miura N, Chang JT, Piwnica-Worms H, Rosen JM, and Mani SA. Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growthOncogene 35, 5977–5988 (2016). [link]

Paranjape AN,  Soundararajan R,  Werden SJ,  Joseph R,  Taube JH,  Liu H,  Rodriguez-Canales J,  Sphyris N,  Wistuba I,  Miura N,  Dhillon J,  Mahajan N,  Mahajan K.,  Chang JT,  Ittmann M,  Maity SN,  Logothetis C,  Tang DG,  Mani SA. Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell propertiesOncogene. 35, 5963–5976 (2016). [link] 

Dhawan A*, Tonekaboni SAM*, Taube JH*, Hu S, Sphyris N, Mani SA & Kohandel M. *co-first authors Mathematical modelling of phenotypic plasticity and conversion to a stem-cell state under hypoxiaScientific Reports. (2016). [link] 


Sarkar TR, Battula VL, Werden SJ, Vijay GV, Ramirez-Peña EQ, Taube JH, Chang JT, Miura N, Porter W, Sphyris N, Andreeff M, Mani SA. GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancerOncogene. (2015). [link]


Liu Y, Zhou R, Baumbusch LO, Tsavachidis S, Brewster AM, Do KA, Sahin A, Hortobagyi GN, Taube JH, Mani SA, Aarøe J, Wärnberg F, Børresen-Dale AL, Mills GB, Thompson PA, Bondy ML. Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancerBreast Cancer Res Treat. 143(1):189-201 (2014). [link] 


Taube, JH Malouf GG, Lu E, Sphyris N, Vijay V, Ramachandran PR, Ueno K, Gaur S, Nicoloso M, Rossi S, Herschkowitz JI, Rosen JM, Issa J-PJ, Calin GA, Chang JT, Mani SA. Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell propertiesSci. Rep. 3, 2687 (2013). [link]  Demonstrated a novel link between microRNA-203 and cancer stem cell properties, prompting further work on this microRNA as mediator of differentiation therapy.

Malouf GG*, Taube JH*, Lu Y, Roysarkar T, Panjarian S, Estecio MR, Jelinek J, Yamazaki J, Raynal NJ, Long H, Tahara T, Tinnirello A, Ramachandran P, Zhang XY, Liang S, Mani SA, Issa JP. *co-first authors Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transitionGenome Biol. 24;14 (12) (2013). [link] Demonstrated the genome-wide epigenetic alterations associated with EMT. 

Zarkoob H., Taube JH, Singh SK, Mani SA, Kohandel M. Investigating the Link between Molecular Subtypes of Glioblastoma, Epithelial-Mesenchymal Transition, and CD133 Cell Surface ProteinPLOS One; 8(5): e64169 (2013). [link]

Hollier BG, Tinnirello AA, Werden SJ, Evans KW, Taube JH, Sarkar TR, Sphyris N, Shariati M, Kumar SV, Battula VL, Herschkowitz JI, Guerra R, Chang JT, Miura N, Rosen JM, Mani SA. FOXC2 Expression Links EMT, Cancer Stem Cell Traits, and Metastasis in Breast CancerCancer Research 73(6):1981-92. (2013). [link]


Taube JH.*, Herschkowitz J.*, Komurov K.*, Zhou A., Yang J., Hartwell K., Onder T., Gupta P., Evans K., Hollier B., Ram P., Lander E., Rosen J., Weinberg R., and Mani S. *co-first authors A Core EMT Interactome Gene Expression Signature is Associated with Claudin-low and Metaplastic Breast Cancer SubtypesPNAS Nov 2; 107(44):19132. (2010). [link] Demonstrated a foundational link between EMT and triple-negative breast cancer subtypes. >500 citations. 

Taube JH., Allton K., Zhu W., Duncan S., Shen L., and Barton M. Foxa1 Functions as a Pioneer Transcription Factor at Transposable Elements in the AFP Promoter During Differentiation of Embryonic Stem CellsJournal of Biological Chemistry. Vol 285, No 21, pp 16135-44 (2010). [link]


Cui R.*, Nguyen T.*, Taube JH.*, Feuerman M., and Barton M. *co-first authors Family members p53 and p73 act together in chromatin modification and direct repression of AFP transcriptionJournal of Biological Chemistry. Vol 280, No 47, pp 39152-39160. (2005). [link]

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