Back: Wezley Griffin (PhD), Dustin Jaoude, Clayton Smith, Keighley Reisenauer, Beatriz Castro-Rodriquez, Alec Ingros, Aadil Sheikh | Front: Tim Philip, Joelle Kim, Dr. Joe Taube, Kelsey Johnson, Taylor Nesbit, Samantha Pena | Inset: Emily Lin

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Research Focus

Outgrowth of disseminated metastases is the major cause of mortality in cancer patients. In the Taube lab, we are investigating the molecular pathways and cellular properties which enable primary tumor cells to metastasize.

In normal tissues, epithelial cells form a well-structured barrier using a variety of adhesion molecules. However, aberrant activation of a conserved cellular program, termed epithelial-mesenchymal transition (EMT), facilitates the separation of epithelial cells from this tissue. When EMT occurs in epithelial tumors, the probability of metastatic dissemination is increased.

Our current work is focused on uncovering the regulatory mechanisms which facilitate EMT in both normal and cancerous settings, describing the specific targets and roles of these regulatory mechanisms and testing small molecule inhibitors of these proteins to ultimately lead to novel therapeutic strategies.

News and Updates

SABCS 2018

We are excited for the San Antonio Breast Cancer Symposium 12/4-8/2018 where both our doctoral students, Keighley and Kelsey, will be presenting their research. Keighley’s abstract on cancer stem cell sensitization to treatment with small-molecules has been...

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Race for the Cure

The Taube Lab is proud to support Susan G. Komen’s Race for the Cure this year, being held in Waco! If you’d like to join our team, or support the cause, follow this link! We are thankful for your...

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